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Notoginsenoside Ft1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Notoginsenoside Ft1图片
CAS NO:155683-00-4
包装:5 mg
市场价:380元

产品名称
三七皂苷FT1
三七皂甙 Ft1
产品介绍
NotoginseNOSide Ft1 是一种植物分离的三七皂苷,具有刺激血管生成的作用。

产品描述

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities

体外活性

Notoginsenoside Ft1 (Ft1) is a novel stimulator of angiogenesis. Ft1 induces proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells (HUVECs). Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways. In addition, Ft1 induces phosphorylation of the mammalian target of rapamycin (mTOR), and siRNA-mediated mTOR knockdown decreases tube formation, proliferation, transport of HIF-1α into nuclei and VEGF mRNA expression in response to Ft1[1].Among the saponins examined, Notoginsenoside Ft1(Ft1) was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel[2].

激酶实验

Platelet aggregation was analysed using a platelet aggregometer. Prothrombin time, activated partial thromboplastin time and thrombin time were measured using a blood coagulation analyser, which was further corroborated with bleeding time and thrombotic assays[2].

Cas No.

155683-00-4

分子式

C47H80O17

分子量

917.14

别名

三七皂苷FT1;三七皂甙 Ft1

储存和溶解度

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years