1-Hydroxyanthraquinone 是口服有效的天然产物,来源于植物Tabebuia avellanedae,显示出致癌活性。
产品描述
1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.
体外活性
1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity[2].
体内活性
Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats[2].
Cas No.
129-43-1
分子式
C14H8O3
分子量
224.21
储存和溶解度
Chloroform:30 mg/mL
DMSO:16.67 mg/mL (74.35 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years