Azadiradione 是HSF1的一种，是由印楝树中提取得到，具有一定生物活性的柠檬苦素。

Azadiradione (AZD) from the methanolic extract of seeds of Azadirachta indica

Azadiradione (AZD)?ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent.?All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes.?Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function.?Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity.?These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide[1].

26241-51-0

C28H34O5

450.575

AZD

DMSO:55 mg/ml (122.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years