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Azadiradione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azadiradione图片
CAS NO:26241-51-0
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AZD
产品介绍
Azadiradione 是HSF1的一种,是由印楝树中提取得到,具有一定生物活性的柠檬苦素。

产品描述

Azadiradione (AZD) from the methanolic extract of seeds of Azadirachta indica

体外活性

Azadiradione (AZD)?ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent.?All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes.?Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function.?Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity.?These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide[1].

Cas No.

26241-51-0

分子式

C28H34O5

分子量

450.575

别名

AZD

储存和溶解度

DMSO:55 mg/ml (122.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years