AP-C5 选择性抑制鸟苷3'，5' 环一磷酸 (cGMP) 依赖性蛋白激酶 II (cGKII)，pIC50为 7.2，可用于腹泻疾病的研究。

AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II ( cGKII ) with a pIC 50 of 7.2, which can be used for the research of diarrheal disease [1].

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue [1]. AP-C5 potentiates cAMP signaling by PDE inhibition [1]. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum [1].

2234272-10-5

C16H13N5

275.31

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years