Psicofuranine also specifically inhibits GMP synthase and interrupts parasite growth. Psicofuramine is a nucleoside antibiotic. It has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine shows dose-dependent inhibition of P. falciparum growth(IC50: 0.3 mM).

The Psicofuranine inhibitory concentration is similar to that of E. coli. Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth [1].

1874-54-0

C11H15N5O5

297.27

DMSO:50 mg/mL (168.20 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years