Triclocarban 是一种抗菌剂，用于个人清洁产品。它有潜在干扰内分泌的作用，具有调节雄激素和雌激素活性以及其他激素介导的生物过程的能力。

Triclocarban, an antimicrobial agent, is used in personal cleaning products.

Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) itself does not increase the population of dead cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells [1]. Triclocarban exerts estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells [2].

Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM[1]. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring[3].

101-20-2

C13H9Cl3N2O

315.58

3,4,4′-Trichlorocarbanilide;Solubacter;Cutisan;Procutene;三氯卡班

DMSO:150 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years