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CK-636(CK-0944636)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CK-636(CK-0944636)图片
CAS NO:442632-72-6
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)284.38
FormulaC16H16N2OS
CAS No.442632-72-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 57 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 50 mg/mL (175.8 mM)
Other info

Chemical Name: N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

InChi Key: ACAKNPKRLPMONU-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)

SMILES Code: O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3

SynonymsCK0944636; CK636; CK-0944636; CK 636; CK 0944636; CK-636
实验参考方法
In Vitro

In vitro activity: CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.

In Vivo
Animal model
Formulation & Dosage
References

Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960.