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N-Acetyl-D-galactosamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Acetyl-D-galactosamine图片
CAS NO:14215-68-0
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
2-乙酰胺基-2-脱氧-D-半乳糖
GalNAc
产品介绍
N-Acetyl-D-galactosamine是一种源自半乳糖的末端必需氨基糖,在人体中形成?? A 型血的抗原。

产品描述

N-Acetyl-d-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans.

体外活性

N-Acetyl-D-galactosamine (GalNAc or D-GalNAc) on the damage induced by SBA on the membrane permeability and tight junction proteins of piglet intestinal epithelium (IPEC-J2) cells. The IPEC-J2 cells were pre-cultured with 0, 0.125 × 10-4 , 0.25 × 10-4 , 0.5 × 10-4 , 1.0 × 10-4 and 2.0 × 10-4 mmol/L GalNAc at different time period (1, 2, 4 and 8 hr) before being exposed to 0.5 mg/ml SBA for 24 hr.Pre-incubation with GalNAc mitigates the mechanical barrier injury as reflected by a significant increase in trans-epithelial electric resistance (TEER) value and a decrease in alkaline phosphatase (ALP) activity in cell culture medium pre-treated with GalNAc before incubation with SBA as both indicate a reduction in cellular membrane permeability. In addition, mRNA levels of the tight junction proteins occludin and claudin-3 were lower in the SBA-treated groups without pre-treatment with GalNAc. The mRNA expression of occludin was reduced by 17.3% and claudin-3 by 42% (p< 0.01). Moreover, the corresponding protein expression levels were lowered by 17.8% and 43.5% (p< 0.05) respectively. However, in the GalNAc pre-treated groups, occludin and claudin-3 mRNAs were reduced by 1.6% (p >0.05) and 2.7% (p< 0.01), respectively, while the corresponding proteins were reduced by 4.3% and 7.2% (p< 0.05). In conclusion, GalNAc may prevent the effect of SBA on membrane permeability and tight junction proteins on IPEC-J2s.

Cas No.

14215-68-0

分子式

C8H15NO6

分子量

221.209

别名

2-乙酰胺基-2-脱氧-D-半乳糖;GalNAc

储存和溶解度

H2O:125 mg/mL (565.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years