5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.

698999-09-6

C10H14ClN5O4

303.7

DMSO:25 mg/mL
Ethanol:0.5 mg/mL
DMF:PBS (pH 7.2)(1:3):0.25 mg/mL
DMF:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years