UUN44923 是脂肪及肥胖相关酶 (FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 可用于研究癌症。摘自专利文献 WO2018157843A1 中的化合物 32。

UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.

2243944-92-3

C18H16Cl2N4O2

391.25

UUN44923

Ethanol:80 mg/mL (199.79 mM)
DMSO:80 mg/mL (199.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years