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Darglitazone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Darglitazone图片
CAS NO:141200-24-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
Darglitazone 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。

产品描述

Darglitazone is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.

体外活性

In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), Darglitazone(30 μM) stimulated the expression of UCP2 gene probably via PPAR-γ and increased uncoupling protein 2 (UCP2) mRNA[1].

体内活性

In male diabetic ob/ob mice, Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24?h of recovery. Normalized blood glucose and reduced circulating triglycerides (TG) and very-low-density lipoproteins (VLDL) in diabetic ob/ob mice without having any effect in the nondiabetic mice. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult[2].

Cas No.

141200-24-0

分子式

C23H20N2O4S

分子量

420.48

储存和溶解度

Ethanol:≤5mg/mL
DMSO:20mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years