Coenzyme Q9 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降，改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。

Coenzyme Q9 (CoQ9) is a normal constituent of human plasma. CoQ9 in human plasma may originate as a product of incomplete CoQ10 biosynthesis or from the diet.

Coenzyme Q9 were cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis[1].

Mutations in the gene that encodes Coenzyme Q9(CoQ9) are associated with encephalomyopathy and autosomal-recessive, neonatal-onset, primary CoQ10 deficiency.While in humans CoQ10 predominates, mice and C. elegans primarily rely on CoQ9 for electron transport through the mitochondrial respiratory chain and for antioxidant functions[2,3].

Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control.?After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion.?Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis.?Samples of hearts were examined for the presence of CoQ9 and CoQ10[1].

303-97-9

C54H82O4

795.246

CoQ9;辅酶Q9;Ubiquinone Q9;Ubiquinone 9

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years