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Aramchol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aramchol图片
CAS NO:246529-22-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
C20-FABAC
产品介绍
Aramchol 是一种胆酸和花生酸的结合物,能够降低硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。它具有用于非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的潜能。

产品描述

Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner.

体内活性

Three months' administration of the fatty acid-bile acid conjugate Aramchol is significantly reduces liver fat content in patients with NAFLD. The reduction in liver fat content occurred in a dose-dependent manner and was associated with a trend of metabolic improvements, indicating that Aramchol might be used for the treatment of fatty liver disease[1].

动物实验

Performed a randomized, double-blind, placebo-controlled trial of 60 patients with biopsy-confirmed NAFLD (6 with nonalcoholic steatohepatitis) at 10 centers in Israel. Patients were given Aramchol (100 or 300 mg) or placebo once daily for 3 months (n = 20/group). The main end point was the difference between groups in the change in liver fat content according to magnetic resonance spectroscopy. The secondary end points focused on the differences between groups in alterations of liver enzyme levels, levels of adiponectin, homeostasis model assessment scores, and endothelial function[1].

Cas No.

246529-22-6

分子式

C44H79NO5

分子量

702.118

别名

C20-FABAC

储存和溶解度

DMSO:53.33 mg/mL (75.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years