4-IPP 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物，也是MIF的不可逆抑制剂。

4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)

4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade.

In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction.?Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation.

Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours

Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks

41270-96-6

C10H7IN2

282.084

4-Iodo-6-phenylpyrimidine

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years