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4-IPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-IPP图片
CAS NO:41270-96-6
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
4-Iodo-6-phenylpyrimidine
产品介绍
4-IPP 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物,也是MIF的不可逆抑制剂。

产品描述

4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)

体外活性

4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade.

体内活性

In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction.?Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation.

细胞实验

Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours

动物实验

Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks

Cas No.

41270-96-6

分子式

C10H7IN2

分子量

282.084

别名

4-Iodo-6-phenylpyrimidine

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years