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Sodium gualenate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium gualenate图片
CAS NO:6223-35-4
包装与价格:
包装价格(元)
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Guaiazulenesulfonate sodium
磺酸钠
产品介绍
Sodium gualenate 是一种桂皮烯的亲水性衍生物,具有良好的抗炎和愈伤活性,常用于十二指肠溃疡,胃溃疡和胃炎的研究。

产品描述

Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound. It has anti-inflammatory and wound-healing effects.

体内活性

Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach[1].

动物实验

The anti-gastric ulcer activity of compounds was tested through an ethanol-induced gastric ulcer mouse model method.?Kunming mice, consisting of both males and females, each weighing about 25 g, were divided into groups of 8 at random.?The tested compounds, Omeprazole and guaiazulene derivatives which were made into suspensions using 5% CMC-Na were administered orally (0.4 mL/20 g) to the dose group, the drug reference group and the GAS-Na group respectively.?While the base control group was treated with only 5% CMC-Na.?Vehicle or test compounds were administered by the oral route once a day for five consecutive days.?After 0.5 h of the last dose, the mice were given orally 0.3 mL of anhydrous ethanol.?Half an hour after anhydrous ethanol administration, the animals were killed.?At last, the stomachs were removed and scored[1].

Cas No.

6223-35-4

分子式

C15H17NaO3S

分子量

300.35

别名

Guaiazulenesulfonate sodium;磺酸钠

储存和溶解度

DMSO:30 mg/mL (99.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years