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Hycanthone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hycanthone图片
CAS NO:3105-97-3
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
海恩酮
Etrenol(mesylate)
Win 249-33
产品介绍
Hycanthone 是 Lucanthone 的生物活性代谢产物,是一种抗血吸虫病药。它是一个噻吨酮类 DNA 嵌入剂,可抑制 RNA 合成以及 DNA 拓扑异构酶 I 和 II。它通过直接蛋白质结合来抑制核酸生物合成并抑制嘌呤内切核酸酶1,KD为 10 nM。

产品描述

Hycanthone is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM).

体外活性

Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% [2].

体内活性

Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules [1].

Cas No.

3105-97-3

分子式

C20H24N2O2S

分子量

356.48

别名

海恩酮;Etrenol(mesylate);Win 249-33

储存和溶解度

DMSO:18 mg/mL (50.49 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years