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Ro60-0175
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ro60-0175图片
CAS NO:169675-08-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Ro60-0175 是一种有效的选择性 5-HT2C 受体激动剂。 Ro60-0175 减少可卡因自我给药和在寻求药物行为消失后恢复反应。

产品描述

Ro60-0175 is an effective and selective 5-HT2C receptor agonist. Ro60-0175 reduces cocaine self-administration and cocaine recovery after drug-seeking behavior disappeared.

体内活性

Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) significantly reduces responding on the active lever in the reinstatement group. Ro60-0175 (1 mg/kg; s.c.) preserves the regularity of responding seen in control animals in the drug-treated group, but drug-treated animals reach their break-points earlier. Ro60-0175 (1 mg/kg; s.c.) reduces responding for cocaine and effect is reversed by SB242084 (0.5 mg/kg; i.p.). Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) with the combination of yohimbine (1 mg/kg; i.p.) dose-dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].

Cas No.

169675-08-5

分子式

C11H12ClFN2

分子量

226.68

别名

Ro60-0175

储存和溶解度

DMSO:120 mg/mL (529.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years