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GSK369796 Dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK369796 Dihydrochloride图片
CAS NO:1010411-21-8
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
N-tert-butylisoquine
产品介绍
GSK369796 Dihydrochloride 是一种抗疟药,可抑制 HERG 钾离子通道复极化,IC50值为 7.5 μM。

产品描述

GSK369796 Dihydrochloride,is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)

体外活性

Analysis of antiviral activities indicated that GSK369796 has high anti-DENV activity in the DENV2 replicon expressing cells with EC50 values of 5.06 ± 0.86 μM. The infectivity assays revealed the EC50 values of 3.03 ± 0.35 μM. The mode of action of this compound is through inhibition of autophagy, thereby affecting DENV2 replication. Moreover, this compounds also showed antiviral activity against the rapidly emerging Zika virus (ZIKV) with EC50 values of 2.57 ± 0.09 μM (GSK369796)[1].

Cas No.

1010411-21-8

分子式

C20H24Cl3N3O

分子量

428.78

别名

N-tert-butylisoquine

储存和溶解度

DMSO:75 mg/mL (174.91 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years