Mavacoxib 是口服长效环氧合酶 2 选择性抑制剂，是长效的非甾体类抗炎药，用于犬退化性关节病相关的炎疼及痛症的研究。

Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.

Mavacoxib is cytotoxic to a panel of human and canine osteosarcoma, mammary and bladder carcinoma cancer cell lines;?that it can induce apoptosis and inhibit the migration of these cells.?Mavacoxib can exert these effects independently of elevated COX-2 expression[1].Mavacoxib has a direct cell killing effect on cancer cells, increases apoptosis in cancer cells in a manner that may be independent of caspase activity, and has an inhibitory effect on cell migration.?Importantly, that cancer stem cells derived from osteosarcoma cell lines are sensitive to the cytotoxic effect of mavacoxib[2]

170569-88-7

C16H11F4N3O2S

385.34

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years