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Epoxyazadiradione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Epoxyazadiradione图片
CAS NO:18385-59-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Epoxyazadiradione 是从印楝果实中得到的柠檬苦素。它能够可逆的、非竞争性的抑制人类、约氏疟原虫、疟原虫的互变异构酶活性。它具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。

产品描述

Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.

体外活性

Epoxyazadiradione exhibits most potent anti-cancer activity in both TNBC and ER+ breast cancer cells.?Epoxyazadiradione induces apoptosis and inhibits PI3K/Akt-mediated mitochondrial potential, cell viability, migration and angiogenesis.?It also inhibits the expression of pro-angiogenic and pro-metastatic genes such as Cox2, OPN, VEGF and MMP-9 in these cells.?Furthermore, epoxyazadiradione attenuates PI3K/Akt-mediated AP-1 activation.Epoxyazadiradione suppresses breast tumor growth and angiogenesis in orthotopic NOD/SCID mice model.

Cas No.

18385-59-6

分子式

C28H34O6

分子量

466.574

储存和溶解度

DMSO:60 mg/ml (128.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years