TBK1/IKKε-IN-2 是双重TBK1和IKKε抑制剂。

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

1292310-49-6

C26H27N5O3

457.52

DMSO:16.5mg/ml (36.06 Mm),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years