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GSK3368715 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK3368715 dihydrochloride图片
CAS NO:1628925-77-8
包装:100 mg
市场价:8787元

产品名称
EPZ019997 dihydrochloride
产品介绍

产品描述

GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.

体外活性

GSK3368715 dihydrochloride ?shows 50% or more growth inhibition relative to DMSO-treated cells in the majority of 249 cancer cell lines, representing 12 tumor types.

体内活性

GSK3368715 dihydrochloride significantly effects on the growth of BxPC3 xenografts at all doses tested, reducing tumor growth by 78% and 97% in the 150- and 300-mg/kg dose groups, respectively.

Cas No.

1628925-77-8

分子式

C20H40Cl2N4O2

分子量

439.46

别名

EPZ019997 dihydrochloride

储存和溶解度

DMSO:250 mg/mL (568.88 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years