Ligustilide 是从当归和川芎中分离出来的一种生物活性邻苯二甲酸酯衍生物,具有神经保护、抗癌、抗炎和血管扩张作用。
产品描述
3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.
体外活性
To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide .
Cas No.
4431-01-0
分子式
C12H14O2
分子量
190.24
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years