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FR054
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FR054图片
CAS NO:35954-65-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品介绍
FR054 是一种己糖胺生物合成途径酶 PGM3 的抑制剂,具有明显的抗乳腺癌活性。它在不同的乳腺癌细胞中诱导细胞增殖和存活显著降低。

产品描述

FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.

体内活性

The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. FR054 (250?μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptotic cell death [1].

Cas No.

35954-65-5

分子式

C28H37N2O16

分子量

657.60

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years