Bis-Tos-PEG4 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。
产品描述
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker. Bis-Tos-PEG4 can be used in the synthesis of PROTACs.
体外活性
PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Cas No.
37860-51-8
分子式
C22H30O9S2
分子量
502.6
别名
PROTAC Linker 16;1,11-Bis(tosyloxy)-3,6,9-trioxaundecane;Tetraethylene glycol di(p-toluenesulfonate)
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years