(S,R,S)-AHPC-PEG2-NH2 dihydrochloride 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 分子的合成。
产品描述
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker[1].
体外活性
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Cas No.
2341796-76-5
分子式
C28H43Cl2N5O6S
分子量
648.6
别名
(S,R,S)-AHPC-PEG2-NH2二盐酸盐;VH032-PEG2-NH2 dihydrochloride;VH032 amide-PEG2-amine;VH032-linker 12
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years