MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体，设计了靶向EED的PROTACs， PROTAC EED degrader-1 和 PROTAC EED degrader-2 。

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design EED-Targeted PROTAC which are EED degrader-1 and PROTAC EED degrader-2 [1].

With 14 days treatment, MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI 50 of 14 nM [1].

2639882-68-9

C23H21FN6O3

448.45

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years