Clofilium tosylate 是一种钾通道阻滞剂，可诱导人早幼粒细胞白血病细胞凋亡，具有抗心律失常作用。

Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.

Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP.. However, the expression of Bcl-2 and Bax proteins does not change significantly[1].

92953-10-1

C28H44ClNO3S

510.17

DMSO:100 mg/mL (196.01 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years