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EC330
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EC330图片
CAS NO:2016795-77-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
EC330 是一种白血病抑制因子抑制剂。

产品描述

EC330, a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range.

体外活性

EC330 blocked formation of colonies in soft agar and inhibited angiogenesis (tube formation) in human umbilical vein endothelial cells. EC330 binds to LIF/LIFR complex by insilico docking studies and reduced the STAT3 phosphorylation in a dose dependent manner through blocking LIF-JAK-STAT signaling. EC330 showed marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. The compound further showed cytoskeletal disruption and targeting cancer associated fibroblasts (CAFs).

体内活性

EC330 treatment (0.5 and 2.5mg/kg) dose dependently reduced tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models.

Cas No.

2016795-77-8

分子式

C30H32F2O2

分子量

462.581

储存和溶解度

DMSO:20 mg/mL (43.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years