Dipyrithione 似乎具有新的细胞毒性和强大的广谱抗肿瘤活性。

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor[1].

Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1].

3696-28-4

C10H8N2O2S2

252.31

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years