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FT011
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FT011图片
CAS NO:1001288-58-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
FT011 是抗纤维化剂,能够抑制胶原蛋白 I 和 III 的 mRNA 表达,减少胶原蛋白合成。

产品描述

FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy.

体内活性

A direct anti-fibrotic agent, FT011, attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy[1].

动物实验

Homozygous Ren-2 rats were randomized to receive streptozotocin or vehicle then further randomized to FT011 (200 mg/kg/day) or vehicle treatment for 6 weeks. Prior to tissue collection, cardiac function was assessed via echocardiography and cardiac catheterization. Total collagen deposition and cardiomyocyte hypertrophy were assessed by picrosirius red and haematoxylin and eosin staining, respectively. Macrophage interstitial infiltration and type I and III collagen were quantitated by immunostaining[1].

Cas No.

1001288-58-9

分子式

C20H17NO5

分子量

351.358

储存和溶解度

DMSO:29 mg/mL (82.54 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years