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INCA-6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
INCA-6图片
CAS NO:3519-82-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Triptycene-1,4-quinone
产品介绍
INCA-6 是活化 T 细胞核因子 (NFAT) 和 calcineurin-NFAT 信号传导的抑制剂。

产品描述

INCA-6 is an inhibitor of Nuclear factor of activated T cells (NFAT) and calcineurin-NFAT signaling.

体外活性

In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation[1]. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation[2]. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells[3]. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin[4].

体内活性

INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner[1].

Cas No.

3519-82-2

分子式

C20H12O2

分子量

284.31

别名

Triptycene-1,4-quinone

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years