LDN-211904 oxalate (compound 32) 是一种有效的选择性EphB3抑制剂，IC50为 0.079 μM。LDN-211904 oxalate 在小鼠肝微粒体中具有良好的代谢稳定性。LDN-211904 oxalate 与西妥昔单抗联用可有效抑制 STAT3 激活的 CSC 干性和 CRC 中的西妥昔单抗耐药性。

LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC 50 of 0.079 μM. LDN-211904 oxalate exhibits good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC [1] [2].

1198408-78-4

C21H21ClN4O5

444.87

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years