5J-4 是一种有效的钙释放激活钙通道 (CRAC) 和钙池操纵性钙内流(SOCE) 阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.

5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation[1].

827001-82-1

C16H12N2O3S

312.34

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years