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BiP inducer X
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BiP inducer X图片
CAS NO:101714-41-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
BIX
产品介绍
BiP inducer X 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP inducer X 可防止神经元和视网膜细胞系中的细胞死亡。

产品描述

BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

体外活性

Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].

体内活性

In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction[1].

Cas No.

101714-41-4

分子式

C9H7NO3S

分子量

209.22

别名

BIX

储存和溶解度

DMSO:45 mg/mL (215.08 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years