KF 38789 特异性的抑制P-selectin与PSGL-1结合。它对 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 的结合具有抑制作用 (IC50:1.97 μM) 。

KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein.

KF 38789, inhibited the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 microM. Cell adhesion to both E-selectin-Ig and L-selectin-Ig were not affected even by 100 microM of KF 38789. Moreover, KF 38789 inhibited P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF 38789 significantly inhibited the TG-induced accumulation of leukocytes in the mouse peritoneal cavity (p<0.01)[1].

KF 38789 significantly reduced mechanical allodynia in the facial carrageenan-injected mice[2].

257292-29-8

C19H21NO5S

375.44

KF 38789

DMSO:<30mg>Powder: -20°C for 3 years
In solvent: -80°C for 2 years