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Wortmannin-Rapamycin Conjugate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Wortmannin-Rapamycin Conjugate图片
CAS NO:1067892-47-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品介绍

产品描述

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.

Cas No.

1067892-47-0

分子式

C88H131N3O23

分子量

1598.99

储存和溶解度

Ethanol:5 mg/mL
DMF:30 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years