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Neuronostatin-13 human acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neuronostatin-13 human acetate图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Neuronostatin-13 human acetate(1096485-24-3 free base)
产品介绍
Neuronostatin-13 human acetate(1096485-24-3 free base) 是一种 13 个氨基酸的肽类激素,在调节激素和心脏功能中起重要作用。

产品描述

Neuronostatin-13 human acetate is a 13-amino acid peptide hormone, which plays an important role in the regulation of hormonal and cardiac function.

体外活性

Treatment with Neuronostatin-13 human acetate (1,000 nM) enhances low-glucose-induced glucagon release compare with islets treated with control medium alone. Treatment with Neuronostatin-13 human acetate for 1 h leads to a significant increase in the accumulation of glucagon mRNA compare with vehicle-treated control cells. In αTC1-9 α-cells, treatment with 100 nM Neuronostatin-13 human acetate leads to an increase in phosphorylated PKA at 30 and 40 min[1].

体内活性

Infusion with Neuronostatin-13 human acetate delays glucose clearance in the rat model, such that blood glucose levels in Neuronostatin-13 human acetate-treated animals are significantly higher at 1 and 10 min following intra-arterial injection of a glucose bolus[1]. Chocardiographic measurement reveals a remarkable drop in heart rate after 3-, 6- and 12-hr of Neuronostatin-13 human acetate challenge. In addition, Neuronostatin-13 human acetate treatment significantly decreases left ventricular end-systolic diameter (LVESD) and fractional shortening without affecting left ventricular end-diastolic diameter (LVEDD) between 6 and 12 hrs following Neuronostatin-13 human acetate challenge, the effect of which returns to basal level 18-hr after Neuronostatin-13 human acetate treatment[2].

Cas No.

TP1827L

分子式

C66H114N20O18

分子量

1475.73

别名

Neuronostatin-13 human acetate(1096485-24-3 free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years