Ioversol 是一种非离子碘化造影剂 (CM)，不损伤动物的血脑屏障 (BBB)，可用于动物实验的 CT 扫描或 x-ray。

Ioversol is a nonionic iodinated contrast agent.

Ioversol significantly increases apoptosis and caspase-3 protein expression in the NRK-52E cells exposed to ioversol for 4 h. Ioversol treatment induces a significant increase in [Ca2+]i and intracellular ROS.Ioversol (100 mg iodine/ml) exposure induces significantly increased lactate dehydrogenase release and decreased 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide conversion in NRK-52E cells.

In comparison with iothalamate, ioversol has a greatly reduced propensity to stimulate the release of endothelin, from cultured cells and when injected into anesthetized rats. Ioversol produces less renal vasoconstriction than does iothalamate, in control and in USIC rats, and the development of radiocontrast nephropathy, assessed by creatinine clearance and morphologic damage to the renal medulla, is largely avoided.

87771-40-2

C18H24I3N3O9

807.11

MP-328;碘佛醇

DMSO:100 mg/mL (123.90 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years