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GRA Ex-25
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GRA Ex-25图片
CAS NO:307983-31-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
GRA-Ex-25
产品介绍
GRA Ex-25 是glucagon受体抑制剂,其对大鼠和人的 glucagon 受体的IC50值分别为 56 和 55 nM。

产品描述

GRA-Ex-25 is an inhibitor of glucagon receptor.

体外活性

GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions[1]. GRA Ex-25 has similar affinity to the rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2].

体内活性

GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose which is caused by exogenous administration of glucagon in rat models. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenously administered glucagon, most likely due to the direct inhibition of glucagon stimulated hepatic glucose output[2].

Cas No.

307983-31-9

分子式

C29H36F3N3O5

分子量

563.618

别名

GRA-Ex-25

储存和溶解度

DMSO:32 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years