AC264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂,pEC50为 7.5。
产品描述
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
Cas No.
1051487-82-1
分子式
C19H18BrN3O2
分子量
400.276
别名
AC264613
储存和溶解度
DMSO:40 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years