K03861 是一种 II 型 CDK2 抑制剂，Kd值是 8.2 nM。它对 CDK2(WT)、CDK2(C118L)、CDK2(A144C) 和 CDK2(C118L/A144C) 的 Kd 分别为 50 nM、18.6 nM、15.4 nM 和 9.7 nM。

K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1]

853299-07-7

C24H26F3N7O2

501.514

K03861

Ethanol:12 mg/mL (23.9 mM)
DMSO:93 mg/mL (185.4 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years