Senexin B 是一种有效的选择性 CDK8/19 抑制剂（CDK8 和 CDK19，Kd 分别为 140 nM 和 80 nM）。

Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).

Senexin B inhibits CDK8/19 in low nanomolar range[1]

In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen[1].

1449228-40-3

C27H26N6O

450.55

4-[[2-[6-[(4-甲基-1-哌嗪基)羰基]-2-萘基]乙基]氨基]-6-喹唑啉甲腈

DMSO:6 mg/mL (13.32 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years