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mTOR inhibitor-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
mTOR inhibitor-3图片
CAS NO:1207358-59-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
mTOR inhibitor-3 是一种mTOR抑制剂,Ki=1.5 nM。在细胞实验及体内药代动力学 (PK)/药效学 (PD) 实验中,它都能够抑制mTORC1和mTORC2。

产品描述

mTOR inhibitor-3 is an inhibitor of remarkably selective mTOR (Ki : 1.5 nM)

体外活性

mTOR inhibitor-3 is an mTOR inhibitsor(Ki of 1.5 nM), 500-fold selectivity over closely related PI3 kinases.?mTOR inhibitor-3 inhibits NCI-PC3 and MCF7neo/Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2].

体内活性

mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls.?mTOR inhibitor-3 has moderate terminal elimination half-life (t1/2=1.7 h for mouse(1 mg/kg, iv))?[2].

Cas No.

1207358-59-5

分子式

C25H30N8O2

分子量

474.56

储存和溶解度

DMSO:45 mg/mL (94.82 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years