您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Tenalisib
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tenalisib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenalisib图片
CAS NO:1639417-53-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
RP6530
产品介绍
Tenalisib 是一种新颖的,高效的,选择性的 PI3Kδ (IC50:25 nM) 和 PI3Kγ (IC50:33 nM) 抑制剂。

产品描述

Tenalisib (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)

体外活性

In both HEL-RS and HEL-RR cells, Tenalisib exhibits modest proliferation inhibition (33-46% inhibition @ 10 μM). Addition of 10 μM tenalisib to ruxolitinib is synergistic resulting in a near-complete inhibition of proliferation (>90% for HEL-RS and >70% for HEL-RR). Addition of 5 μM tenalisib, 4 h prior to the addition of ruxolitinib results in a significant reduction in EC50of ruxolitinib (5.8 μM) in HEL-RR cells.

体内活性

Single agent(Tenalisib) activity is evident in difficult-to-treat subjects at ≥ 200 mg BID[2].

Cas No.

1639417-53-0

分子式

C23H18FN5O2

分子量

415.42

别名

RP6530

储存和溶解度

DMSO:100 mg/mL (240.72 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years