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N,N'-Dimethylthiourea
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N,N'-Dimethylthiourea图片
CAS NO:534-13-4
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
DMTU
N,N-二甲基硫脲
产品介绍
N,N'-Dimethylthiourea 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (?OH) 的清除剂,通过活化的中性粒细胞在体外阻止 ?OH 的产生。N,N'-Dimethylthiourea 通过发挥 ?OH 清除和抗炎作用,防止水浸限制应激诱导的大鼠胃粘膜损伤。

产品描述

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] .

体内活性

N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1]. DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response.

Cas No.

534-13-4

分子式

C3H8N2S

分子量

104.17

别名

DMTU;N,N-二甲基硫脲

储存和溶解度

DMSO:250 mg/mL (2399.92 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years