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AP-III-a4 hydrochloride(1177827-73-4 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AP-III-a4 hydrochloride(1177827-73-4 free base)图片
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ENOblock hydrochloride
AP-III-a4 hydrochloride
产品介绍

产品描述

AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate.

Cas No.

T6759L

分子式

C31H44ClFN8O3

分子量

631.18

别名

ENOblock hydrochloride;AP-III-a4 hydrochloride

储存和溶解度

DMSO:53 mg/mL (83.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years