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dTRIM24
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
dTRIM24图片
CAS NO:2170695-14-2
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍

产品描述

dTRIM24, based on PROTAC, is a selective bifunctional TRIM24 degrader.

体外活性

dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. Near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment, which is consistent with a sustained proliferative defect observed following dTRIM24 treatment [2].

Cas No.

2170695-14-2

分子式

C55H68N8O13S2

分子量

1113.3

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years