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AZD3229
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD3229图片
CAS NO:2248003-60-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
AZD3229 是一种突变型酪氨酸激酶受体抑制剂,可用于胃肠道间质瘤的研究。

产品描述

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel.

体内活性

Following a single dose (AZD3229, 20 mg/kg), high free cover over the target is achieved and is associated with complete suppression of pKIT and downstream markers out to 8 hours. As the compound is cleared and cover declines, these signals recover although recovery is not complete even at 24 hours.

Cas No.

2248003-60-1

分子式

C24H26FN7O3

分子量

479.516

储存和溶解度

H2O:Insoluble
DMSO:95 mg/mL (198.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years