AZD3229 是一种突变型酪氨酸激酶受体抑制剂,可用于胃肠道间质瘤的研究。
产品描述
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel.
体内活性
Following a single dose (AZD3229, 20 mg/kg), high free cover over the target is achieved and is associated with complete suppression of pKIT and downstream markers out to 8 hours. As the compound is cleared and cover declines, these signals recover although recovery is not complete even at 24 hours.
Cas No.
2248003-60-1
分子式
C24H26FN7O3
分子量
479.516
储存和溶解度
H2O:Insoluble
DMSO:95 mg/mL (198.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years