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(±)-Norcantharidin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Norcantharidin图片
CAS NO:29745-04-8
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
去甲斑蝥素
Norcantharidin
Endothall anhydride
产品介绍
(±)-Norcantharidin 是一种人类结肠癌中 c-Met 和 EGFR 的双重抑制剂,可研究抗癌,具有抗血管生成活性。

产品描述

Endothall Anhydride is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.

体内活性

NCTD might be a useful and inexpensive drug candidate to substitute for gefitinib to serve the treatment needs of cancer patients[1].NCTD inhibits the growth of xenografted tumors of human gallbladder carcinoma in nude mice by inducing apoptosis and blocking the cell cycle in vivo[2].

细胞实验

Two human colon cancer cell lines, HCT116 and HT29, were used as model systems to investigate the anti-cancer molecular mechanism of NCTD. Cell cycle arrest and early/late apoptosis were analyzed by flow cytometry. The levels of EGFR, phospho-EGFR, c-Met, phospho-c-Met and other related proteins were quantified by western blot analysis[1]

动物实验

The tumor xenograft model of human gallbladder carcinoma in nude mice in vivo was established with subcutaneous GBC-SD cells. The experimental mice were randomly divided into control, 5-FU, NCTD, and NCTD+5-FU groups which were given different treatments. Tumor growth in terms of size, growth curve, and inhibitory rate was evaluated. Cell cycle, apoptosis, and morphological changes of the xenografted tumors were assessed by flow cytometry and light/electron microscopy. The expression of the cell cycle-related proteins cyclin-D1 and p27 as well as the apoptosis-related proteins Bcl-2, Bax, and survivin were determined by the streptavidin-biotin complex (SABC) method and RT-PCR[2].

Cas No.

29745-04-8

分子式

C8H8O4

分子量

168.148

别名

去甲斑蝥素;Norcantharidin;Endothall anhydride

储存和溶解度

DMSO:33 mg/mL (196.25 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years